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Drug interactions of folic acid

Drug interactions


 Vitamin C and folic acid with the service, can inhibit the gastrointestinal absorption of folic acid in a large number of vitamin C, folic acid will accelerate the discharge, so the intake of vitamin C in 2g or more people must increase the amount of folic acid; antibiotics can affect the microbiological method for the determination serum or red blood cell folate concentrations, low concentrations of the phenomenon of emergence. Are using phenytoin (antiepileptic drugs), or estrogen, sulfa drugs, phenobarbital (sleeping pills and tranquilizers), aspirin, folic acid intake should be increased; will take a lot of intake of folic acid two phenyl hydantoin epilepsy patients have cramps. Methoxy pyridine chatter, pyrimethamine and so on dihydrofolate reductase has a strong pro-afterburner, can prevent folate into tetrahydrofolate, folic acid treatment discontinued.

 

 In addition, the inhibition of dihydrofolate reductase drugs such as methotrexate, trimethoprim, and interfere with folate absorption of certain drugs such as anticonvulsants, oral contraceptives can reduce plasma concentrations of folic acid, can cause severe giant erythroblastic anemia, which is by these two drugs in the cell metabolism of the final common pathway for this.

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