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Resveratrol anti-cancer, anti-mutagenic effect

Resveratrol anti-cancer, anti-mutagenic effect
1993, Jayafilake other studies have shown that trans-resveratrol and cis-resveratrol has anti-cancer activity, the reason is that they can inhibit the protein - tyrosine kinase activity. Jang and other research team further noted that the resveratrol in the three stages of cancer that start, the promotion and development process, has a greater anti-cancer activity, and the three stages of cancer have a role in inhibiting or even reversing :
First, inhibition of the starting role. Reduce free radical formation, induced an increase in phase Ⅱ enzyme pharmacokinetics, the role of dioxin antagonist;
Second, to enhance the role of inhibition. Inhibition of cyclooxygenase (COX), inhibition of catalase; three inhibiting development role. Inhibition of cancer cell proliferation and induce cell differentiation, induction of apoptosis. Resveratrol is expected as an inhibitor of protein tyrosine kinase PTK, a lot of medical research found that resveratrol in breast cancer, stomach cancer, colon cancer, prostate cancer, leukemia, ovarian cancer, skin cancer and other malignant cells were inhibited.

In January 1997, the United States University of Illinois at Chicago College of Pharmacy Professor John Pezzutos research team in the famous U.S. "Science" magazine, published an article entitled "Grapes of natural product anti-cancer activity of resveratrol," the paper, caused a sensation medical scientific community. Papers that resveratrol can inhibit cancer cell activity related to the process. As an antioxidant, anti-mutagenic agents and anti-inflammatory agent, resveratrol showed cancer chemopreventive ability to prevent cancer cell carcinoma lesions and prevent the proliferation of chromium can inhibit protein tyrosine kinase, kinase function by blocking from the anti-mutagenic effects, but also inhibit inflammation.

Resveratrol can also inhibit inflammation. The cell inflammation associated with arthritis and other diseases. Resveratrol can also inhibit the protein tyrosine kinase tyrosine phosphorylation of the catalytic material. The kinases included in the regulation of mitotic cell signal transduction in the cytoplasm. The use of resveratrol inhibit protein tyrosine kinase, may function by blocking kinase sky anti-mutagenic effect.

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